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Contraindications include personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), as tirzepatide carries a boxed warning regarding thyroid C-cell tumors observed in rodent studies

(High levels mimic menopause)

doi:10.1056/NEJMoa2028198 Obesity Medicine Association

Biochimica et Biophysica Acta (BBA) - Mol Basis Disease 7:166133 Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA et al (2004) Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

"I scoffed at people saying you need electrolytes but you really do!" u/ElectrolyteBeliever Low blood pressure Weight loss, reduced salt intake, or improved cardiovascular health may alter blood pressure

Because it's designed to suppress appetite and enhance satisfaction with smaller food portions