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However, when the landmark trials of semaglutide (STEP 1) and tirzepatide (SURMOUNT-1) measured body composition, they found that in some analyses, around 40% of weight loss came from LBM

To facilitate reduction in disease progression and risk of carcinoma, abstinence from alcohol and smoking is necessary

This lowers your blood pressure and helps reduce the strain on your heart, blood vessels, and kidneys

On a drug this expensive, that adds up fast

Therefore, the heterogeneities in cardiovascular medication, baseline characteristics, study population, and study design should be taken into consideration when comparing the results among these trials

Accordingly, claims of long-term structural renoprotection should be interpreted cautiously until kidney-focused trials and longer follow-up data confirm benefits on hard renal endpoints (eGFR slope, ESKD)
