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At 40 weeks, tirzepatide 5 mg, 10 mg, and 15 mg produced greater HbA1C reductions and greater weight loss than semaglutide 1 mg

Switching from Injectable to Oral# Recommendation : Orforglipron Reason : ATTAIN-MAINTAIN showed that patients switching from injectable semaglutide or tirzepatide to oral orforglipron maintained their previously achieved weight loss, validating oral step-down therapy

As a Functional Diagnostic Nutrition Practitioner (FDNP) , I am always expanding my knowledge of aging and metabolic health

doi: 10.1016/j.ejphar.2021.174310 47 HansenDVHansonJEShengM

This preserves muscle mass during weight loss, which is critical for maintaining metabolic rate and avoiding the "skinny fat" outcome that can result from losing weight too quickly without adequate protein

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