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This lends further weight to prospective investigation of the benefits and safety of GLP-1 RAs in the real world which are resumed in Table 2

To name just one example, tirzepatide shows a 64% lower risk of gastroparesis compared to semaglutide in non-diabetic patients [22]

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Sixteen state Medicaid programs the federal and state initiative that provides free health insurance to low-income people covered the drugs for obesity in October 2025 (though, notably, most states cover GLP-1 drugs for diabetes)