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The 4.5 mg dose produced 10.8% mean weight loss at 26 weeks

When someone has a significant amount of weight to lose, not eating as much initially- no matter the type of food- will cause a calorie deficit

Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, Gelfand JM (2017) Psoriasis and comorbid diseases: epidemiology

For individuals managing obesity or weight-related health conditions, clinical treatments that mimic metabolic hormones have fundamentally shifted therapeutic expectations

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These agents consistently reduced exogenous insulin requirements and facilitated modest improvements in glycemic control and even enabled temporary insulin independence in a few cases