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As a GLP-1 (glucagon-like peptide-1) receptor agonist, Ozempic stands out from other medications in its class due to several unique characteristics that directly benefit our patients

What are all the GLP-1 side effects by body system

Parkinsons disease, characterized by dopaminergic neuronal loss in the substantia nigra leading to motor and non-motor symptoms, has also been linked to insulin resistance and impaired cerebral insulin signaling.128 GLP-1RAs and GLP-1/GIP dual-receptor agonists have demonstrated the capacity to enhance insulin sensitivity and exert antioxidant and anti-inflammatory effects in the brain.129 Preclinical studies in various PD animal models indicate that GLP-1RAs such as liraglutide, semaglutide, and lixisenatide promote dopamine synthesis and elevate striatal dopamine levels, thereby conferring neuroprotection to dopaminergic neurons.130132 The dual agonist telpor similarly exhibits neuroprotective effects by improving energy metabolism and inhibiting inflammatory pathways in PD models.126 Clinical trials have assessed the efficacy and safety of GLP-1RAs in PD patients with PD

Proper dosing schedules become essential because higher doses lead to more frequent side effects such as gastrointestinal upset, and the side effects can be managed by using the minimum effective dose or slow titration (Figure 2)

Tools like cognitive behavioural strategies and emotional resilience coaching can help individuals: Identify triggers and automatic eating patterns Replace negative thinking with healthier coping strategies Build structure, accountability, and sustainable habits Transition off medication gradually and confidently Motivation WMs approach is the Mental Weight assessment , designed to explore an individuals relationship with food, stress, emotions, and self-perception