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Semaglutide itself does not directly cause vaginal dryness, but the rapid fat loss it produces can reduce estrogen levels because adipose tissue produces estrogen through aromatization

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Dosing considerations: Most GLP-1 medications dont require dose adjustment for mild-to-moderate kidney impairment, though severe impairment may affect some options

Currently, there is no direct evidence that GLP-1RA use contributes to progression of pancreatic cysts to PDAC, but this remains an important knowledge gap for future investigations considering the high prevalence of pancreatic cysts in the general population (~ 10% by age 50 and ~25% by age 70) 56

Keep a water bottle accessible throughout the day and establish regular drinking habits

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