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However, the principal strength of this study was the long-term observation, providing the first insights into a potential novel strategy for partially overcoming adaptive mechanisms following the cessation of semaglutide-induced weight loss in insulin-resistant populations

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Pharmacologic agents to assist in weight loss [83] include medications that assist in weight loss as a side effect, such as topiramate (anti-epileptic), roflumilast (COPD), bupropion and fluoxetine (depression), and methylphenidate (stimulant)

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