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Those two conflicting theories are illustrated in Fig

This case study highlights GLP-1s role in preventing complications that could shorten lifespan

The pervasive stereotype that plagues folks in larger bodies is that fast food and ultra-processed foods are to blame

GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake

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As these medications promote weight loss and alter fluid balance, the cardiovascular system may adjust heart rate to maintain adequate cardiac output and tissue perfusion