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It represents a fundamental shift in how obesity should be treated in clinical practice
Different weight regain was observed in subjects with different characteristics
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Mechanistic hypotheses include reduced leptin-driven T-helper (Th)1/Th17 activity, improved adipokine balance, and modulation of gut-thyroid axis pathways
The gut barrier helps maintain separation between the intestinal environment and the rest of the body, supporting digestive health, immune balance, and overall gut function
