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This comparison is noteworthy not just for the efficacy data, but for the strategic divergence in mechanism: while tirzepatide and other dual agonists activate the GIP receptor alongside GLP-1R, MariTide takes the opposite approach by blocking GIPR while activating GLP-1R

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[DOI] [PubMed] [Google Scholar] 23.Trujillo J.M., Nuffer W., Smith B.A

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