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Even the best medicine gives better results when supported by a proper obesity-management strategy

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This initial recognition step allows the peptides N-terminus to engage deep within the receptor TMD core, triggering a conformational change proximal to the intracellular region that results in G protein coupling and activation of the downstream signalling cascade 3,4,5,6,7

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You can read the full article at Tirzepatide, a new dual GIP/GLP-1 receptor agonist administered once weekly, is currently being developed as a treatment for type 2 diabetes (T2D) and obesity