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This article examines the potential relationship between tirzepatide therapy and changes in stool characteristics, including when to seek medical attention

We addressed incoherence (inconsistency) both locally by comparing directly with indirect evidence using the Separating Indirect from Direct Evidence (SIDE) method [19] and globally using the design-by-treatment interaction model [20]

Decreased appetite was the second most common adverse event

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Current guidelines might not precisely advise on the weight loss magnitude needed to improve health outcomes as obesity management should be individualized, but most agree on a reduction of between 5% and 10% for individuals with a body mass index (BMI) 25 kg/m 2 and at least 10% for those with complication-specific goals [4,5,6,7]