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STEP studies)

[DOI] [PubMed] [Google Scholar] 49.Facciorusso A., Straus Takahashi M., Eyileten Postula C., Buccino V.R., Muscatiello N

This article provides a summary of the weight reduction effectiveness, glycemic control, and safety of semaglutide (up to a 2.4-mg dose) and tirzepatide (up to a 15-mg dose), with a focus on the Semaglutide Treatment Effect in People with Obesity (STEP) 2, SURPASS-1, and SURPASS-2 trials, which involved patients with type 2 diabetes mellitus

This is consistent with central sensitization research more broadly, where initial sensitization episodes lower the threshold for future episodes

Some happen because of weight loss you cant see on a scale or because of modifications to food intake

I have the drive and I have the willingness and I have the motivation, but I have not been able to lose weight in all the conventional ways. Swenson writes for the Associated Press.