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Some use vitamin B12 as an additive

substantial fat loss may shift this hormonal balance

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Im not taking away from the manufacturers who developed it because Im not eligible to get their product

And the study protocol registered to UMIN-CTR (No.UMIN000024556) approved by International Committee of Medical Journal Editors (ICMJE)

Despite the promising efficacy of these agents, it is essential to consider their safety profiles, particularly regarding gastrointestinal adverse effects, which are common but generally transient and manageable