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When thyroid function tests change, the shifts are usually small and appear to relate to weight loss and broader metabolic changes

It mimics the effects of the GLP-1 hormone, which helps to increase insulin secretion, decrease glucagon levels, and slow gastric emptying to improve glycemic control

These cells are critical regulators of glomerular perfusion and pressure and are intimately involved in a physiological process known as tubuloglomerular feedback (TGF) (10), which is detailed below

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Slow dose escalation mitigates these effects substantially, and discontinuation due to gastrointestinal intolerance ranges from 3% to 16% across agents, being highest for GLP-1/glucagon dual agonists (e.g., survodutide)

Stress, boredom, or other emotional triggers can lead to overeating, even when physical hunger isnt a factor