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GIP receptors are co-expressed with GLP-1Rs in the arcuate nucleus (ARC) and may act synergistically through PI3K/AKT signaling to reinforce anorexigenic output and insulinotropic responses [45]

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Long-acting formulations typically lead to fewer nausea and vomiting complaints but are associated with higher rates of diarrhoea

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36 It has shown promise in improving fibrosis in MASH while achieving significant weight loss
