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Highlights from the findings Heart and kidney protection

As a result, scientists are increasingly attempting to combine GLP-1 RAs with other hormone-based medications or engineer them as dual or triple receptor agonists to enhance their efficacy in treating obesity while mitigating side effects

International Journal of Molecular Sciences , 23 (17), 9583

JCI Insight 5 , e140532 (2020)

In support of this notion, subcutaneously administered LUXendin645, an Ex9based GLP1 receptor antagonist, has been demonstrated to have an overlapping distribution with PPG axons in the arcuate nucleus (Ast et al., 2020)

Enhanced autophagy, the cellular process by which damaged or misfolded proteins are identified and cleared, was observed, suggesting improved capacity to remove the amyloid and tau aggregates that accumulate in neurodegeneration