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While it may seem surprising that treating diabetes would worsen one of the diseases complications, this seemingly paradoxical relationship is well-established: any treatment that abruptly lowers blood glucose can accelerate DR

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Dosage and Administration Protocols Dosing is highly individualized and is based on the patients current treatment, effectiveness, and tolerability

By preserving beta-cell function through the incretin system and reducing insulin resistance through metformin, researchers are evaluating if this combination can delay the need for insulin therapy longer than other oral agents