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The OOS flag reflects what the vendor's website displayed

doi:10.1056/nejmoa2032183

Dose optimization: Genetic polymorphism testing for CYP2D6 enzyme activity is required to guide dose adjustment, preventing excessive HPA axis suppression that could lead to abnormally low cortisol levels

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Similarly, FTO gene variants (rs9939609) correlate with differences in hunger signaling and gastrointestinal tolerance, meaning two patients on identical doses may experience vastly different side-effect profiles

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