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Semaglutide interacted with circumventricular organs, where GLP-1R expression is abundant, and with regions protected by the BBB (lateral septal nucleus, nucleus tractus solitarius, hypothalamic arcuate nucleus) (136)

The result is lower peak hormone concentrations and reduced overall hormonal exposure

Mahapatra MK, Karuppasamy M, Sahoo BM

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F., et al
