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To investigate whether QMP would secure a long plasma half-life of a GLP-1 albumin fusion, we constructed a recombinant fusion protein with the identical amino acid sequence as Tanzeum (albiglutide-mimic: GLP-1 WT), as well as a modified version containing the QMP substitutions (GLP-1 QMP) (Fig

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Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1c targets

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