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Cognition improved in exenatide treated patients in fluid intelligence (baseline 38.4 (8.2), 12 weeks 52.9 (6.6), p=0.0005), processing speed (baseline 43.7 (9.4), 12 weeks 58.4 (10.4), p=0.0058) and episodic memory (baseline 49.4 (5.3), 12 weeks 62.1 (13.2), p=0.0315)

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Led by graduate student Jordan Miller '25 and Professor David Han, the team studied national poison control center data and identified a sharp rise in semaglutide-related calls following the FDAs 2021 approval of the medication for chronic weight management

Stopping GLP-1 medications like semaglutide before surgery requires careful timing coordinated with your surgical team

We also address current barriers to implementation and evidence-based use, ongoing clinical trials, and future directions, including combination therapies that may enhance efficacy and patient outcomes.

Background Guidelines recommend combination therapy with glucagonlike peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) for cardiorenal risk reduction in people with type 2 diabetes (T2D)