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This prompted Moore's group to study the effects of duodenal extracts given daily by mouth to three patients recently diagnosed with juvenile diabetes (type 1)

Front Pharmacol

External triggers like psychological stress, trauma, or viral infections can activate the condition in those genetically susceptible to the disorder

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If gastrointestinal symptoms are problematic, adjusting the timing may be considered, with reassessment after several weeks

In vitro studies demonstrated that treatment with liraglutide or exendin-4 significantly attenuated oxidative stress and cellular apoptosis in SH-SY5Y cells exposed to methylglyoxal or high glucose, which mimicked the pathophysiological conditions of diabetic neuropathy [79, 80]