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Beeson, J

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Tell trusted friends about your journey and join online communities like the active Reddit forums at r/glp1 and r/WegovyWeightLoss

Eli Lilly's Phase 3 TRIUMPH-4 trial results for retatrutide were announced yesterday, and the numbers are nothing short of remarkable: 28.7% weight reduction at 68 weeks with the 12mg dose

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However, native GLP-1 is always easily degraded by dipetidylpeptidase IV (DPP IV) to produce some N-terminally truncated metabolites in vivo, followed by rapid clearance (half-life is around 2 min), preventing its broad applications 8