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It is what semaglutide and tirzepatide have delivered in real-world clinical practice over 2024 and 2025 - and that gap is instructive

All of this meant that I would eat past the point of comfort

The pharmacy benefit manager Prime Therapeutics published an analysis last summer that highlights this ongoing challenge with respect to the real-world effectiveness over time of the GLP-1 drugs used to treat obesity: Most overweight or obese patients without diabetes stop treatment within the first few years

This article covers the pharmacological half-life of the .25 mg dose, the factors that influence its clearance, and what you can expect as the medication leaves your system

Diabetes 63:24862497 Nauck MA, Petrie JR, Sesti G et al (2016) A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes

Always ensure at least 72 hours between any two doses