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Diarrhea: Gastrointestinal discomfort, including diarrhea, may appearparticularly with higher doses or rapid dose increases

Protein intake deserves special attention

While many patients acclimate within weeks, others continue to struggle for months

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Interestingly enough, the review also found that the tirzepatides Mounjaro and Zepbound were linked to higher rates of telogen effluvium and, consequently, more hair loss

Similar results were observed in an experiment involving a germ-free mouse strain, where the animals transplanted with microbiome isolated from depressed patients showed an increase in immobility time in the forced swim test and a decreased proportion of central motion distance in the open field test, compared to mice transplanted with bacteria obtained from healthy control subjects [101]