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Several mid-stage trials will read out in 2025 to provide important proof points for novel MoAs and their potential for differentiation, e.g., Lillys bimagrumab (activin/myostatin type II receptor inhibitor) in combination with semaglutide, aiming to deliver weight loss while preserving muscle mass (phase 2b)

The five inputs worth tracking before selecting anything: protein intake, electrolytes and hydration, resting heart rate, sleep quality, and training output

If an experimental drug reduces disease progression and results in less need to change symptomatic medications, an imbalance in medication changes between groups can potentially mask or underestimate the true benefits of the new therapy 8

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