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Additionally, neither male (Supplemental Figure 1, KP) nor female (Supplemental Figure 1, QV) heterozygous Bbs5 +/ mice displayed any discernable phenotypic changes compared with WT controls

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S.AshrafA.et al (2024)

They used population pharmacokinetic/pharmacodynamic (PK/PD) modeling to analyze tesofensine and its metabolite, as well as cognitive assessment scale data from 62 mild AD patients in placebo-controlled studies