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Secondary, safety and negative control endpoints For individual components of the primary endpoint, semaglutide versus sitagliptin reduced myocardial infarction (HR 0.81, 95% CI 0.70 to 0.92) and stroke (HR 0.84, 95% CI 0.71 to 0.99) in the expanded populations at low, moderate and high cardiovascular risk

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Georgios Schoretsanitis, lead author of a separate study, acknowledged no clear evidence of a causal relationship between semaglutide and suicidal ideation, but noted a potential association

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