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For patients prioritizing weight loss without exercise, injection therapy typically produces superior results

Patients are advised to eat smaller, more frequent meals rather than large portions, as this reduces the burden on an already-slowed digestive system

Valenzano A, Tartaglia N, Ambrosi A, Tafuri D, Monda M, Messina A, et al

The benefit lasted for the full three-month observation period, even though weight loss was modest and statistically non-significant. The authors concluded, GLP-1R agonists appear to effectively reduce migraine burden regardless of weight loss, highlighting a possible pathophysiological role of CSF volume and pressure regulation in migraine