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Nutrients, 16 (3), 509

Ozempic (Semaglutide for Diabetes) Available in South Africa since 2019 Approved use: Type 2 diabetes management Dosage: Lower doses (up to 1 mg once weekly in SA, higher doses like 2 mg in some markets) Average weight loss: 10-20% of body weight in clinical trials Other benefits: Improves blood sugar control, lowers HbA1c, reduces cardiovascular risks in diabetics In South Africa, Ozempic is not officially approved for weight loss , though some doctors prescribe it off-label to help with obesity

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The specific neuronal populations that express Glp1r and mediate anti-inflammatory effects, including brainstem populations implicated in peripheral immune sensing, have not been identified