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Gilbert MP, Pratley RE

About 4% of patients discontinue tirzepatide due to intolerable side effects

Most patients who go off the drug cannot successfully maintain their target weight without maintenance

Its not yet clear what aspects of Ozempic are linked, though some predict it could be how the drug affects stomach motility and digestion with the gastrointestinal tract

That rate of progress tends to support a better balance between fat loss and muscle preservation, especially when combined with adequate protein intake and strength training