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J Endocrinol 264(2):e240210 McIntyre RS, Mansur RB, Rosenblat JD, Rhee TG, Cao B, Teopiz KM, Wong S, Le GH, Ho R, Kwan ATH (2025) Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase)

While weight loss trends aren't new to the American cultural experience, glucagon-like peptide-1 receptor agonists (colloquially referred to as GLP-1 medications), are the center of the national conversation about weight loss

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explicit disclosure that compounded medications are not FDA-approved finished drug products

indeed, although it reaches the brain via endocrine mechanisms, it also acts locally by activating GLP-1R present on the dendritic terminals of the vagus nerve that innervate the gut, thus mediating the inhibition of food intake as well as relaying the satiety signal to the brain
Kushner RF, Calanna S, Davies M, et al
