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In APP/PS1 transgenic mice, (D-Ser2)Oxm, a dual GLP-1 and Gcg receptor agonist, notably improves spatial memory and synaptic plasticity, reduces A plaque deposition in the hippocampus, and modulates the PI3K/AKT1/GSK3 signaling pathway [84]

10.1016/j.diabet.2021.101223 [DOI] [PubMed] [Google Scholar] 25

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Use of CRISPR/Cas9-engineered INS-1 pancreatic cells to define the pharmacology of dual GIPR/GLP-1R agonists

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans
