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If sexual changes do occur during Ozempic treatment, several indirect mechanisms may be responsible, rather than a direct pharmacological effect on sexual function

In failing heart tissue, the uptake and metabolism of these substrates are compromised, reducing oxidative phosphorylation and energy production [54]

According to the 2025 World Obesity Atlas, the number of obese people will increase by 115% (from 524 million to 1.13 billion) between 2010 and 2030

However, as more people consider reducing or stopping their use of the drug, its important to understand how to maintain good health during this transition

Acknowledgments DJD is supported by a Banting and Best Diabetes Centre-Novo Nordisk Chair in Incretin Biology, a Sinai Health Novo Nordisk Foundation Fund in Regulatory Peptides, and CIHR Foundation Grant 154321

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