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What to Expect When Starting Tirzepatide Through PlexusDx First-time tirzepatide users typically begin with a low starting dose and titrate upward every two to four weeks based on tolerance and clinical response

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Others may restrict coverage based on diagnosis, medical necessity, or specific plan benefits

For weight management, guidelines recommend reassessment approximately 12 weeks after reaching a maintenance dose to determine whether to continue therapy, though weight loss may continue beyond this timeframe in some patients

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