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The risks of doing so including infection, incorrect dosing, and adverse reactions without medical support are substantial

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Remarkably, RETA-induced protection extends to a lung cancer model with 50% reduced tumor engraftment, significantly delayed tumor onset, and mitigated tumor progression, with a 17-fold reduction in tumor volume compared to controls

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Furthermore, GPR17 signaling studies have heavily relied on cell models with limited physiological relevance (e.g., HEK293 cells) and these studies indicate complex G protein coupling patterns and second messenger signaling profiles [2628