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Targeting inflammation to treat diabetic kidney disease: the road to 2030
[1] [2] The physiologic role of GLP-1 includes stimulating glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

2009;587(Pt 19):47494759

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Other studies back this up, showing that long-term exposure reduces the drug's effects [25]

As well as endogenous GLP-1,GLP-1 receptor agonists also have numerous other effects such as promoting weight loss, deceleration of gastric emptying, lowering blood pressure (systolic and diastolic), and lowering total cholesterol ( Figure 1
