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Ongoing Follow-Up and Treatment Adjustment GLP-1 weight loss treatment is not a one-time intervention

However, it should be emphasized that use of caloric restriction to control for weight-dependent effects in DIO mouse studies may potentially introduce confounding effects on microbiome signatures due to significant compensatory changes in hunger sensation, feeding pattern, resting metabolic rate and gut morphology which may be disproportionately to that attained by appetite suppressants 80,81

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Green tea deserves special mention: its catechins (especially EGCG) have been shown to inhibit DPP-IV activity in adipose tissue (view study), potentially preserving GLP-1 levels by slowing its breakdown the same mechanism targeted by DPP-IV inhibitor drugs

This variable pattern of state coverage decisions also raises important health equity issues