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Our clinicians prefer to classify these medications as incretin mimetics, which include drugs that act as GLP-1s, GLP-1/GIPs, and others

GLP-1RAs compared to placebo In addition, the pooled results showed that first line use of GLP-1RAs has a significant predisposing effect on diarrhea (OR: 2.18, 95% CI: 1.32, 3.60

Moreover, clinical investigations have revealed that GLP-1 analogues can alleviate the severity of psoriasis in patients with T2DM

These findings represent substantial improvements over traditional anti-obesity medications and approach the efficacy levels historically associated with bariatric surgery

Meta-Analyses and Real-World Evidence A 2021 meta-analysis of major CVOTs confirmed a 14% MACE reduction (HR 0.86, 95% CI 0.80-0.93) with GLP-1 agonists, with significant reductions in MI, stroke, cardiovascular death, and all-cause mortality [51]
