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semaglutide 2.4 Efficacy and safety of once-weekly 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial Ozempic® (semaglutide) injection 0.5 mg,
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The induction of GLP-1 or its analogs in the liver can regulate varieties of processes, including hepatic gluconeogenesis, glycogen synthesis, and glycolysis [32]
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Retatrutide Phase 2 data showed insulin resistance reductions of over 50% from baseline at higher doses, with fasting insulin levels dropping by up to 71%
[DOI] [PubMed] [Google Scholar] 80
Off-label use for weight management requires provider evaluation
