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Hypothalamic dysfunction is a common finding in PWS and it has been implicated in several manifestations of this syndrome such as hyperphagia, temperature instability, high pain threshold, sleep disordered breathing, and multiple endocrine abnormalities

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Modern biology (INP 2.0 view) GLP-1 is secreted by intestinal L-cells and regulates insulin secretion, glucagon suppression, gastric emptying, satiety, -cell survival, gutbrain signaling, and inflammation

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