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Recommended protocol: Washout: 25 to 30 days Starting dose: 2mg weekly Week 5: escalate to 4mg Week 9: escalate to 8mg Week 13: escalate to 12mg based on response This accelerated schedule saves 4 weeks compared to the standard titration

Within the abdomen, imagine a grid on either side of the navel (stay away from the belly button itself) and move to a different square each time that area comes up

Using the HA-PVA mixture, it was possible to produce microneedles with enough mechanical strength (0.4 N) to pierce the skin

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Over the course of the study, this amount may be incrementally increased to minimize potential side effects, culminating in a maximum recommended dose of 12mg/weekly