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Stopping the drug usually causes weight regain

While these adverse effects are uncommon, they can be very serious

For danuglipron, most AE were mild in severity at the phase 2 trial for people with T2D, but 2234% of participants receiving the higher doses (80 mg twice daily) discontinued the medication due to AE (vs

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However, the study could not adjust for differences in the rate of normalization of the blood sugar, or the baseline severity of DR, as well as its rate of worsening

For most patients with obesity, the cardiovascular and metabolic benefits of these medications substantially outweigh theoretical concerns about blood clots, which are not supported by current evidence
