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In this pooled analysis of patients with heart failure and preserved ejection fraction across the SELECT, FLOW, STEP-HFpEF and STEP-HFpEF diabetes trials, semaglutide significantly reduced the risk of cardiovascular death or worsening heart failure as compared with placebo, as well as worsening heart failure events alone, but the effects on cardiovascular death were not significant, Mikhail Kosiborod, MD, FACC, FAHA, cardiologist at Saint Lukes Mid America Heart Institute and professor of medicine at the University of Missouri-Kansas City School of Medicine, said during a presentation

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doi: 10.1590/1414-431x20165826 [DOI] [PMC free article] [PubMed] [Google Scholar] 47.Skurikhin E, Pershina O, Pakhomova A, et al
Glucose and fat have been reported to be strong GLP-1-secretagogues after they have been ingested (Reference Elliott, Morgan and Tredger23) , or directly administered into the intestine (Reference Rocca and Brubaker24,Reference Roberge and Brubaker25) or into perfused ileal segments (Reference Cordier-Bussat, Bernard and Levenez26)

Like Semaglutide and breastfeeding , Semaglutide and alcohol also have limited clinical data and research

CagriSema , a combination of cagrilintide (an amylin analog) and semaglutide, is another promising option that adds amylin receptor activation to GLP-1 agonism
