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For this reason, tirzepatide should not replace prescribed hypertension medications unless a healthcare provider determines it is appropriate

It is akin to the CREDENCE (Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy) trial for sodium-glucose cotransporter-2 inhibitors (SGLT2is) in ushering a new agent to slow the progression of kidney diseases in diabetes

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The researchers did not analyze whether patients had a prior history of gout, which could also influence risk

Additionally, epigenetic differences, such as increased methylation of protective genes, such as DUSP9, in females, may influence insulin sensitivity and drug response [49, 51]

GLP-1 effects on cholesterol vary by individual baseline status, medication type, and dosage