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Potent GLP-1 agonists exert effects by multiple mechanisms including delayed gastric emptying, increased glucose-dependent insulin secretion, reduced glucagon levels, and reduced food intake by CNS effects to cause appetite suppression

E., Hamman, R

According to the **TRIUMPH-1 Phase 3 trial results published by Eli Lilly in May 2026**, Retatrutide at the 12mg maintenance dose produced an average of 28.3% body weight reduction over 80 weeks

Its ability to improve glycemic control, along with its benefits in weight reduction, are well-established

In phase 2 and phase 3 trials, cagrilintide produced dosedependent weight loss with a predominantly gastrointestinal sideeffect profile [4] [5]

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