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The SURMOUNT trials showed continued improvement in depression scores through week 72

This actually makes the 505(b)(2) value-added path more attractive as it relies on clinical differentiation rather than just price

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GLP-1/antisense conjugates have been developed to bypass a refractory nature of pancreatic -cells to the uptake of antisense oligonucleotides while harnessing the untapped potential of these oligonucleotides to repress the expression of pathological intracellular targets [951]

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But as we age, chronic stress, poor sleep, toxins, and processed foods blunt that GLP-1 signaling
