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In the pivotal SURPASS clinical trial program evaluating tirzepatide for type 2 diabetes, approximately 4-5% of patients developed anti-tirzepatide antibodies during the study periods, which ranged from 40 to 52 weeks

A Next-Generation Medication with Dual Hormone Action Tirzepatide mimics two natural hormones: GLP-1 regulates appetite, slows digestion, stabilizes blood sugar GIP enhances insulin sensitivity, optimizes energy utilization, supports fullness This dual action produces stronger improvements in metabolic health and body weight compared to GLP-1-only medications for many patients

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References Chong B, Kong G, Shankar K, Chew HSJ, Lin C, Goh R, et al
